O3+Maqui is a unique softgel capable of relieving dry eyes by supporting natural tear production and helps to decrease symptoms associated with Dry Eye and other ocular diseases. O3+Maqui is specifically formulated to offer a precise dosage combination of 2,745 mg of purified, highly-refined omega-3 and 100 mg of MaquiBright (maqui berry extract) in a single unigel.
In a recent study, O3+Maqui in combination outperformed omega-3, maqui extract, and placebo on OSDI, DED Score Assessment, MMP-9 and Corneal Staining. Patients experienced a 91% increase in tear film breakup time and a 78% improvement in symptom scores. Dietary supplements of re-esterified omega-3 fish oil and standardized maqui berry extract outperformed re-esterified omega-3 fish oil alone as a treatment for dry eye disease. 
O3+Maqui represents an effective approach to restore comfort and composition of one’s tears and eye moisture. A natural dietary supplement can soothe your eyes from the inside out by stimulating healthy tear production to restore your eye’s delicate ecosystem. 
Each O3+Maqui softgel contains 100 mg of MaquiBright, the purified extract of maqui berries. Maqui berries are fruits from the maqui (Aristotelia chilensis) tree native to South America in the Valdivian temperate rainforests of Chile and adjacent regions of southern Argentina. The maqui berries have been used for centuries in traditional medicine and have recently been hailed as a superfood.  Maqui berries are known for their high antioxidant capacity and medicinal properties that include anti-inflammatory, anti-diabetic, and analgesic effects. 
Notably, maqui berry extracts have been reported to be effective in treating certain ophthalmic disorders. In clinical trials, subjects with moderate dry eye symptoms who took 60mg daily of MaquiBright saw a significant increase in tear production and improvements in dry eye related symptoms.
MaquiBright also has up to 30x more antioxidant ability than Acai berries. Studies conducted by the NEI found that supplementing your diet with high levels of antioxidants can improve both tear stability and quantity- alleviating the symptoms of dry eye and may help slow the progress of moderate to advanced age-related macular degeneration, potentially delaying vision loss. Antioxidants also protect against eye damage from things like sunlight, cigarette smoke, and air pollution. 
MaquiBright improved tear fluid production in all study participants after 30 and 60 days of treatment.
The group supplemented with 60 mg MaquiBright per day showed statistically significant tear production increase after 30 and 60 days of treatment.
MaquiBright delphinidins have the ability to be absorbed into the cells of the lachrymal gland, protecting cells from oxidative stress, hence restoring healthy tear fluid production.
Study participants treated with 30 or 60 mg per day of MaquiBright experienced significant symptom relief related to eye dryness, using a validated Dry Eye Quality of Life questionnaire.
MaquiBright was proven to be superior to other berry extracts for restoration of healthy tear fluid secretion. MaquiBright also improves symptoms, like irritation, blurred vision, and sensitivity to light. 
A study, published in the peer-reviewed journal Lipids in Health and Disease, found that triglyceride-form of Omega-3 to be the most effective when compared to other omega-3 products in the marketplace. This is better tolerated with less gastrointestinal side effects. 
Results showed the natural triglyceride form was 382% more effective than krill oil, 227% more effective than salmon oil, and 47% more effective than ethyl ester fish oil. 
Maqui berry can help treat people who are suffering from dry eye. By supporting the natural tear production and reducing light-induced damage to tear glands, maqui berry is more effective at treating dry eye than commercial eye drops. 
Supplementing maqui berry with omega-3 fatty acids also helps to boost the production of the oily layer and slows the evaporation of tears. 
 Paul, D., Jr. (2019). A Combined Regimen of Dietary Supplements Containing Omega-3 Fish Oil and Standardized Maqui Berry Extract Improves Dry Eye Related Symptoms in a Pilot Randomized Interventional Clinical Study. Journal of Clinical & Experimental Ophthalmology, 10(2). doi:10.4172/2155-9570.1000795
 Misle E, Garrido, E., Contardo, H., & González, (2011) W. Maqui [Aristotelia chilensis (Mol.) Stuntz]-the amazing Chilean tree: A review. J Agric Sci Technol 1:1.
 Romanucci V, D’Alonzo D, Guaragna A, (2016) Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Effects. Curr Pharm Biotechnol. 176: 513-523.
 Antioxidants: In Depth. (2016, May 04). Retrieved from https://nccih.nih.gov/health/antioxidants/introduction.htm
 Hitoe, S., Tanaka, J., & Shimoda, H. (2014, September). MaquiBright™ standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25208615
 Giannaccare, G., Pellegrini, M., Sebastiani, S., Bernabei, F., Roda, M., Taroni, L., . . . Campos, E. C. (2019, January 29). Efficacy of Omega-3 Fatty Acid Supplementation for Treatment of Dry Eye Disease: A Meta-Analysis of Randomized Clinical Trials. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/30702470/
 Office of Dietary Supplements – Omega-3 Fatty Acids. (2018, November 21). Retrieved from https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
 Drouault-Holowacz, S., Bieuvelet, S., Burckel, A., Rigal, D., Dubray, C., Lichon, J., . . . Chiambaretta, F. (2009). Antioxidants Intake and Dry Eye Syndrome: A Crossover, Placebo-Controlled, Randomized Trial. European Journal of Ophthalmology, 19(3), 337-342. doi:10.1177/112067210901900302